Epilepsy Clinical Trial
Official title:
Clinical-genetic Investigations in Children With Early Infantile Epilepsies
The project strives to discover novel genetic defects that cause monogenic epilepsy or that
genetically modify a preexisting epileptic phenotype. Our main aim is to find genetic causes
for the idiopathic West Syndrome (infantile seizures) that are not caused by known cerebral
malformation, lissencephaly or metabolic disorders and which have a comparatively benign
prognosis.
The investigators hypothesize that mutations in genes coding for ion channels or genes that
modify the action of ion channels might be causative.
For that the investigators will perform a sequence analysis of the coding exons of a large
set of genes in all recruited patients and verify found mutations in their parents.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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Phase 1/Phase 2 | |
| Completed |
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N/A | |
| Completed |
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N/A | |
| Terminated |
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Phase 3 | |
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N/A | |
| Completed |
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N/A | |
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|
||
| Completed |
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N/A | |
| Completed |
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| Recruiting |
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| Active, not recruiting |
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N/A | |
| Recruiting |
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||
| Not yet recruiting |
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N/A | |
| Not yet recruiting |
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Comorbidities of Epilepsy(Cognitive and Psychiatric Dysfunction)
|
||
| Completed |
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Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use
|
Phase 4 | |
| Completed |
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N/A | |
| Completed |
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||
| Recruiting |
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Phase 1 | |
| Terminated |
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N/A | |
| Completed |
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N/A |