Epilepsy Clinical Trial
Official title:
Phase 1 Study for Measuring the Effect of Antiepileptic Drugs on Mitochondrial Activity
This study is based on the hypothesis that antiepileptic drugs (other than Valproic acid)
have an effect on the mitochondrial oxidative phosphorylation.
The objective of this study is to evaluate this effect in an accessible tissue—human
peripheral white blood cells.
Antiepileptic drugs adverse reactions, including hepatotoxicity, are rare but potentially
fatal, especially among children. Although the mechanism of the liver toxicity remains
elusive, mitochondrial oxidative stress, has been hypothesized to play a role.
Most of the studies addressing antiepileptic drug effects on the mitochondria discuss the
effect of valproic acid. The exact mechanisms involved in the drug-induced effects on
oxidative phosphorylation are still far from being resolved. Most of the studies investigated
the effect of valproic acid by using animal models or different in vitro
methods.Mitochondrial diseases should be considered as a risk factor for valproic
acid-induced hepatotoxicity, and there is a consensus for avoiding the administration of the
drug for these patientsIs it possible that other antiepileptic drugs have similar effects?
The knowledge regarding the effects of other antiepileptic drugs on the mitochondria is
relatively scarce.
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