Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

Epilepsy Clinical Trial

Official title:

Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT00851331
• Other study ID #: 3391
• Status: Not yet recruiting
• Phase: N/A
• First received: February 24, 2009
• Last updated: February 24, 2009

Study information

• Verified date: February 2009
• Source: University Hospital, Strasbourg, France
• Contact: Gabrielle Rudolf, PhD, HDR
• Phone: (33) 3.88.11.66.62
• Email: Gabrielle.Rudolf[@]chru-strasbourg.fr
• Is FDA regulated: No
• Health authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
• Study type: Interventional

Clinical Trial Summary

Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development. Childhood focal epilepsies particularly are age-related diseases mainly occurring during developmental critical period. A complex interplay between brain development and maturation processes and susceptibility genes may contribute to the development of various childhood epileptic syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are different syndromes that are considered as part of a single continuous spectrum of disorders. While genetic component in those three syndromes remains elusive, novel and high throughput genome analyzes could bring interesting insights into the possible genetic defects and pathophysiological mechanisms underlying and linking the various disorders associating epilepsy with speech and cognitive impairments.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 0
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 4 Years and older

Eligibility

Inclusion Criteria:

• iodiopathic focal epilepsy with cognitif deficit

Exclusion Criteria:

• medical history of status epilepticus

Study Design

N/A

Related Conditions & MeSH terms

• Epilepsies, Partial
• Epilepsy

Intervention

Genetic:
• genome analyzes (genetic defects and pathophysiological mechanisms )

Locations

Country	Name	City	State
France	Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique	Bron	69500
France	American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A	Reims
France	Clinique neurologique, Hôpitaux Universitaires de Strasbourg	Strasbourg
France	Hôpital de Hautepierre, Service de pédiatrie 1	Strasbourg

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France,