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NCT00006059 Clinical Trial

Genetic Study of Familial Epilepsy

Epilepsy Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00006059
Other study ID # NCRR-M01RR00645-2635
Secondary ID CPMC-IRB-4465
Status Completed
Phase N/A
First received July 5, 2000
Last updated June 23, 2005
Start date January 1997

Study information
Verified date December 2003
Source National Center for Research Resources (NCRR)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

OBJECTIVES:

I. Determine the chromosomal regions that contain genes that raise the risk of epilepsy in families by performing genetic linkage analysis of idiopathic/cryptogenic epilepsy.

Description:

PROTOCOL OUTLINE: Family histories are obtained, then the patients undergo an interview, a neurological examination, and EEG. Blood specimens are also collected.

Linkage analysis is performed on specimens and analysis of shared marker alleles are used to identify genomic regions likely or unlikely to contain the epilepsy genes. Genotypes in family members are determined at microsatellite markers throughout the genome. Markers tested include chromosomes linked to human epilepsy syndromes (6p, 8p, 8q, 20q, 21q) and chromosome 3 (similar to mouse "epilepsy" genes). Linkage to markers on chromosome 10q are also tested.

Patients do not receive the results of the testing and the results do not influence the type and duration of any treatment.

Recruitment information / eligibility
Status Completed
Enrollment 898
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Male or female members of families with at least 1 close relative pair (sibling, half sibling, avuncular, grandparent-grandchild, or first cousin) affected with idiopathic/cryptogenic epilepsy that developed before age 25

Study Design

Primary Purpose: Screening

Related Conditions & MeSH terms

Locations
Country Name City State
United States Columbia University College of Physicians and Surgeons New York New York

Sponsors (2)
Lead Sponsor Collaborator
National Center for Research Resources (NCRR) Columbia University

Country where clinical trial is conducted

United States, 

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