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Grafting of Epidermolysis Bullosa Wounds Using Cultured Revertant Autologous Keratinocytes

Epidermolysis Bullosa Clinical Trial

Official title:
Grafting of Epidermolysis Bullosa Wounds Using Cultured Revertant Autologous Keratinocytes

Clinical Trial Summary

The term epidermolysis bullosa (EB) is used to describe a group of genetic skin diseases associated with skin weakness, blisters, and chronic wounds. "Revertant mosaicism" means that there are two genetically different populations of cells due to spontaneous mutations. Some EB patients have normal, non-fragile skin patches which may be areas of revertant mosaicism. In the revertant areas, the proteins function normally, like non-EB skin. In this study, we plan to culture cells from the revertant areas and graft them on to the wounded areas.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01454687
Study type Interventional
Source Stanford University
Contact
Status Withdrawn
Phase N/A
Start date October 2011
View Details
See also
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Completed NCT04227106 - Phase 3, Open-label Clinical Trial of EB-101 for the Treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB) Phase 3