Eosinophilic Esophagitis Clinical Trial
Official title:
Effects of Swallowed Corticosteroids on Bone Mineral Density and Growth Velocity in Children With Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is characterized by allergy-driven inflammation of the
esophagus leading to a variety of gastrointestinal symptoms and increased healthcare
utilization. While considered a rare disease, EoE is rapidly increasing in prevalence in the
United States. Treatment options are limited and include dietary modifications with the
elimination of suspected food triggers or pharmacological options including proton pump
inhibitors (PPIs) and swallowed corticosteroids. Compliance to strict elimination diets is
difficult thus many patients elect to use swallowed corticosteroids. Because nearly half of
all EoE patients are treated with swallowed corticosteroids there is a growing concern
regarding the long-term effects of this class of medication.4
It is known that oral corticosteroids can compromise bone mineral density and growth
velocity5-7. Furthermore, there have been multiple studies exploring the relationship between
inhaled corticosteroids (ICS) and endocrine effects in asthmatics. While the risk of ICS use
is less compared to systemic corticosteroids, higher ICS doses do cause deleterious effects
on growth and bone health8-11. Currently, there are no published studies examining the effect
of swallowed corticosteroids on bone mineral density or growth velocity in patients with EoE.
Given the route of administration, there may be more systemic absorption leading to a higher
risk of long-term complications.
The proposed work will address the following specific aims:
Specific Aim 1: Assess effects of swallowed corticosteroids on bone mineral density (primary
outcome) in children 5-12 years of age with EoE compared to age matched controls.
Specific Aim 2: Evaluation of the effect of swallowed corticosteroids on growth velocity.
n/a
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