Study to Image the Esophagus Using the OFDI Capsule

Status Completed

Clinical Trial Summary

The main purpose of this research is to test the feasibility and tolerability of the tethered capsule Optical Frequency Domain Imaging (OFDI)

Clinical Trial Description

A total of 56 subjects with Barrett's Esophagus, EoE and healthy volunteers will be asked to swallow the OFDI capsule while being unsedated. The capsule is attached to a tether that allows the capsule operator to navigate the capsule as it progresses down the esophagus using natural propulsion called peristalsis as well as to bring it back up to pulled out of the mouth when the procedure is done.

As the capsule progresses down the esophagus, multiple, two dimensional, microscopic cross- sectional images of the esophagus are acquired. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02204150
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Completed
Phase	N/A
Start date	February 2012
Completion date	July 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03382678` - CEGIR 7807: Validation of Online Cohort of EGID Patients Enrolled in RDCRN CEGIR Contact Registry
Completed	`NCT05083312` - Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 Trial	Phase 3
Completed	`NCT04593251` - Dose Escalation Study to Evaluate an Experimental New Treatment (CALY-002) in Healthy Subjects and Subjects With Celiac Disease and Eosinophilic Esophagitis	Phase 1
Completed	`NCT03633617` - Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)	Phase 3
Completed	`NCT04941742` - The Use of Fractionated Exhaled Nitric Oxide in the Diagnosis and Assessment of Disease Activity of Eosinophilic Esophagitis (Validation Phase)
Terminated	`NCT04543409` - A Study of Benralizumab in Patients With Eosinophilic Esophagitis	Phase 3
Terminated	`NCT02314455` - Esophageal Absorption in EoE	N/A
Completed	`NCT01953575` - Mucosal Impedance and Eosinophilic Esophagitis	N/A
Completed	`NCT01386112` - Safety and Tolerability Study of Oral EUR-1100 to Treat Eosinophilic Esophagitis	Phase 1/Phase 2
Recruiting	`NCT04991935` - Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis	Phase 3
Not yet recruiting	`NCT05896891` - San Raffaele EoE Biobank
Active, not recruiting	`NCT05482256` - A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis	N/A
Recruiting	`NCT05485155` - Zemaira Eosinophilic Esophagitis Pilot Study	Phase 2
Recruiting	`NCT04149470` - Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)	Phase 4
Recruiting	`NCT04416217` - Eosinophilic Esophagitis Steroid Safety Study
Completed	`NCT05084963` - A Study to Assess the Efficacy, Safety and Tolerability of IRL201104 in Adults With Active Eosinophilic Esophagitis	Phase 2
Completed	`NCT02579876` - Milk Patch for Eosinophilic Esophagitis	Phase 2
Recruiting	`NCT02331849` - Esophageal Motility in Eosinophilic Esophagitis Evaluated by High Resolution Manometry.	N/A
Active, not recruiting	`NCT02202590` - Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus	N/A
Active, not recruiting	`NCT05176249` - Prospective Database for Eosinophilic Esophagitis (EoE) of Pediatric Population