Molecular Basis of Food Allergy

Status Enrolling by invitation

Clinical Trial Summary

The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells and cytokines in the development of food allergy. The study also explores these factors in development of tolerance "outgrowing" food allergy. It will also explore the genetic factors that lead to the development of food allergy. The study examines all type of food allergy including IgE mediated reactions, Eosinophilic Esophagitis and Food Protein Induced Enterocolitis

Clinical Trial Description

Food Allergy (FA) is a common pediatric atopic disease. Characteristically children affected by FA become sensitized to food in the first few months of life and spontaneously outgrow the disease by 5-6 years of age in about 80% of cases. At the present time, diagnosis of FA is made by a combination of history, skin testing and food challenge. The pathogenic mechanisms leading to food sensitization and subsequent spontaneous tolerance development are not understood. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01832324
Study type	Observational
Source	Children's Hospital of Philadelphia
Contact
Status	Enrolling by invitation
Phase
Start date	January 2011
Completion date	December 2030

View Details

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