COVID-19 Acute Respiratory Distress Syndrome Clinical Trial
Official title:
The Role of Early Enteral Nutrition in Critical Patients With COVID-19: A Retrospective Study
| Verified date | November 2023 |
| Source | Ankara City Hospital Bilkent |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
The goal of this observational study is to determine the relationship between the nutritional profile of critically ill patients diagnosed with COVID-19 and disease severity, prognosis, and survival, to assess the ability to meet nutritional goals, EN complications, and reasons for discontinuation and postponement of feeding. The main questions aim to answer are the relationship between the duration of EN initiation and Prognostic Nutritional Index (PNI) score, neutrophil-lymphocyte ratio (NLR), oxygenation status, MV, ICU, and length of hospital stay, overall mortality, and whether nutritional goals were met, EN complications, and reasons for discontinuation and postponement.
| Status | Completed |
| Enrollment | 135 |
| Est. completion date | November 20, 2022 |
| Est. primary completion date | October 15, 2022 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 19 Years to 100 Years |
| Eligibility | Inclusion Criteria: - patients diagnosed with COVID-19 - aged 19 years and older - on MV - receiving only enteral tube nutrition Exclusion Criteria: - patients with an inflammatory disease - myocardial infarction, collapse, and circulatory shock within the last 6 months - hemodynamic instability - embolism and stroke - presence of unspecified coma - renal disease - cancer with a mortality rate of more than 50% within 6 months - allogeneic bone marrow transplantation within 5 years - enteral nutrition was contraindicated - patients with allergic reactions to the enteral formula - patients who received antioxidant supplements during feeding - patients who received tube feeding supplemented with immunonutrition agents - patients whose data could not be accurately retrieved |
| Country | Name | City | State |
|---|---|---|---|
| Turkey | Ankara City Hospital | Ankara |
| Lead Sponsor | Collaborator |
|---|---|
| Ankara City Hospital Bilkent | Baskent University |
Turkey,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | mechanical ventilation (MV), intensive care unit (ICU), length of hospital stay and overall mortality. | The research outcomes are to determine the relationship between the duration of EN initiation and MV, ICU, and length of hospital stay, overall mortality. | through study completion, an average of 9 months | |
| Primary | Prognostic Nutritional Index (PNI) score, neutrophil-lymphocyte ratio (NLR), oxygenation status | The research outcomes are to determine the relationship between the duration of EN initiation and Prognostic Nutritional Index (PNI) score, neutrophil-lymphocyte ratio (NLR), oxygenation status | From date of hospitalization and intubation until the date of extubation or date of death from any cause, whichever came first, assessed up to 9 months | |
| Primary | Whether Nutritional goals were met, EN complications, and reasons for discontinuation and postponement. | The research outcomes are to determine the relationship between the duration of EN initation and nutritional goals were met, EN complications, and reasons for discontinuation and postponement. | From date of intubation until the date of extubation or date of death from any cause, whichever came first, assessed up to 9 months |