Enlargement of Tonsil or Adenoid Clinical Trial
Official title:
Analysis of Clinical, Pathologic and Molecular Markers of Adenotonsillar Hypertrophic Disease
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms. The present trial examines potential bioclinical markers of the disease.
Background: Tonsils and adenoids comprise the main bulk of Waldeyer's ring, which is commonly
enlarged in childhood, until the age of 11. Obstructive sleep apnea caused by adenotonsillar
hypertrophy is a major contributing factor to cardiorespiratory morbidity in the pediatric
population. It is also responsible for otitis media with effusion, the most frequent cause of
children's hearing loss. Even so, there is scarce knowledge of its molecular pathogenesis.
Objective: Identification of clinical/molecular markers of adenotonsillar enlargement and
investigation of their participation in the process of tissue hypertrophy.
Methods: A prospective cohort of children with adenotonsillar hypertrophy were recruited
starting on 02/01/2017 and ending on 12/22/2017. Demographic and clinical data including age,
gender, sleep apnea severity, tonsillar size, presence of middle ear effusion, family
history, review of systems as well as tympanometric and complete blood count results were
recorded. Blood samples and tissue specimens from the therapeutic adenotonsillectomy
procedure were archived for future analyses. Children with chronic tonsillitis and/or
adenoiditis, who also underwent excision of tonsils and/or adenoids served as study controls.
Informed consent was obtained from parents of all study participants.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01349205 -
Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
|
N/A |