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NCT01041066 Clinical Trial

Nicardipine Versus Labetalol During Intubation

Endotracheal Intubation Clinical Trial

Clinical Trial Details — Status: Unknown status

Administrative data
NCT number NCT01041066
Other study ID # nicardipine-labetalol
Secondary ID
Status Unknown status
Phase N/A
First received December 30, 2009
Last updated December 30, 2009
Start date September 2009

Study information
Verified date September 2009
Source Seoul National University Bundang Hospital
Contact Jung-Hee Ryu, Ph.D
Phone 82-31-787-7497
Email jinaryu@lycos.co.kr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Recruitment information / eligibility
Status Unknown status
Enrollment 70
Est. completion date
Est. primary completion date December 2009
Accepts healthy volunteers No
Gender All
Age group 20 Years to 65 Years
Eligibility Inclusion Criteria:

- Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

- Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• labetalol
0.4 mg/kg labetalol intravenously 4 min before intubation
• nicardipine
20 ?/kg nicardipine intravenously 4 min before intubation

Locations
Country Name City State
Korea, Republic of Seoul National University Bundang Hospital Seongnam-si Gyeonggi-do

Sponsors (1)
Lead Sponsor Collaborator
Seoul National University Bundang Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate) preinduction- 10 min after intubation
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