Ethnic Differences in the Inflammatory Response in Systemic Inflammation

Endotoxemia Clinical Trial

Official title: Ethnic Differences in the Inflammatory Response in Systemic Inflammation

Status Completed

Clinical Trial Summary

The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.

Clinical Trial Description

Recent data show that there are significant disparities among genders and races in the incidence of sepsis. While men are consistently more likely to have sepsis than women, the apparent racial disparities are even more striking, approaching a doubling of the risk for sepsis among Afro-Americans. Most prominent is the risk among black men, the group in which sepsis occurs at the youngest age and results in the most deaths. Potential mechanisms for heterogeneous susceptibility to sepsis include genetic differences, which have been explored according to sex but not according to race, and other social and clinical factors.

The goal of this study is to explore whether proinflammatory and procoagulant responses in a well standardised inflammation model are comparable in healthy Caucasian and African volunteers. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Educational/Counseling/Training

Related Conditions & MeSH terms

• Endotoxemia

• NCT number: NCT00284869
• Study type: Interventional
• Source: Medical University of Vienna
• Status: Completed
• Phase: Phase 1
• Start date: January 2006
• Completion date: April 2006