Blockade of Vascular Potassium Channels During Human Endotoxemia

Status Completed

Clinical Trial Summary

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Endotoxemia

Clinical Trial Details

NCT number	NCT00185003
Study type	Interventional
Source	Radboud University
Contact
Status	Completed
Phase	Phase 1
Start date	January 2003
Completion date	June 2005

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