Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

Endothelial Dysfunction Clinical Trial

Official title:

The Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03801486
• Other study ID #: 15-16-133
• Status: Completed
• Start date: March 2, 2016
• Est. completion date: May 1, 2017

Study information

• Verified date: January 2019
• Source: Montclair State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators examined the effects on post-digestion brachial artery flow mediated dilation (FMD) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.

Description:

The purpose of the current study was to examine in-vitro and in-vivo effects of replacing 40% of semolina flour with sprouted chickpea flour for the use in pasta. Antioxidant capacity in-vitro was measured by Trolox Equivalent Antioxidant Capacity. Brachial artery flow-mediated dilation, a test of in-vivo endothelial function, was performed for assessment of effects on post-digestion endothelial function. The investigators hypothesized that FMD would be higher after consuming 40% of semolina flour with sprouted chickpea flour pasta vs. 100% of semolina flour pasta.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: May 1, 2017
• Est. primary completion date: May 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy adult

Exclusion Criteria:

• have diabetes mellitus, kidney disease, a history of cancer, cardiac issues, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions.

• food allergies relevant to wheat, gluten, chickpea, and pasta sauce.

• are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.

• are unable or unwilling to refrain from recreational drug (marijuana, cocaine, etc.) or alcohol use during the 24 hours prior to your exercise session.

• use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).

• are pregnant or trying to become pregnant.

Related Conditions & MeSH terms

• Endothelial Dysfunction

Intervention

Other:
• Experimental: Sprouted Chickpea Flour
255g of pasta with 40% sprouted chickpea flour and 60% semolina flour (SCF40) with butter.
• Control: Semolina Flour
255g of pasta with 100% semolina flour (SEM100) with butter.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Montclair State University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-digestion flow mediated dilation	Post meal	Two hours following meal