Endothelial Dysfunction Clinical Trial
Official title:
Effect of Endothelin Receptor Antagonist Bosentan in Glucose Metabolism of the Myocardium and Coronary Dependant Endothelial Vasoreactivity Measured by 18F-FDG PET / CT and 82Rb PET / CT in Patients With PAH or CTEPH
The purpose of this study is to assess the effect of bosentan on the myocardial metabolism
and the dependent endothelial coronary vasomotoricity in patients presenting a PAH.
Hypothesis : Bosentan may improve right ventricular function by decreasing myocardial stress
and glucose metabolism. Patients may benefit from images with 18F-FDG PET / CT and 82Rb PET /
CT for an earlier assessment and optimal management of PAH.
Patients refered to the hospital for a right heart catheterization for a PAH suspected at the
echocardiography will be presented with the protocol.If inclusion/exclusion criteria are
fulfilled all the procedures will be planned. At the screening visit the patient will have a
right heart catheterization and an echocardiography. After a maximum of 4 weeks each patient
will have 18F-FDG and 82Rb PET/CTs before start of treatment with Bosentan. These PET/CTs
together with an echocardiography will be repeated at 6 and 12 weeks after start of treatment
with bosentan.
Finally a right heart catheterization will be planned at 12 weeks after start of treatment
with bosentan as a routine procedure.
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