Exercise and Repetitive Diving

Endothelial Dysfunction Clinical Trial

Official title:

The Impact of Predive Exercise on Repetitive SCUBA Diving

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02118207
• Other study ID #: 264816-02
• Status: Completed
• Phase: N/A
• First received: April 16, 2014
• Last updated: April 16, 2014
• Start date: October 2013
• Est. completion date: January 2014

Study information

• Verified date: April 2014
• Source: University of Split
• Contact: n/a
• Is FDA regulated: No
• Health authority: Croatia: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.

16 divers in 2 groups each completed 6 dives. One group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. The other group completed the opposite protocol. Flow-mediated dilation (FMD) data and blood for MP analysis was collected before and after each dive. VGE were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. Exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% VO2max effort.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: January 2014
• Est. primary completion date: November 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Certified SCUBA diver

• Certified to dive by experienced Medical evaluator

• Must be able to run continuously for 45 min

Exclusion Criteria:

• Prior diagnosis of decompression sickness

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Decompression Sickness
• Endothelial Dysfunction
• Neutrophil Activation
• Venous Gas Emboli

Intervention

Other:
• Aerobic running exercise
60 min of aerobic intervals completed prior to SCUBA diving

Locations

Country	Name	City	State
Croatia	University of Split School of Medicine	Split
United States	University of Maryland	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
University of Split	University of Maryland

Countries where clinical trial is conducted

United States,  Croatia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in circulating microparticle counts	Change in circulating microparticle counts measured pre and post SCUBA diving following 6 dives spaced over 12 days	2 weeks	No