Endothelial Dysfunction Clinical Trial
— CAPaHOfficial title:
Cycling, Air Pollution and Health
Verified date | October 2012 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Interventional |
Introduction: Cycling is currently promoted at the municipal, provincial and national level
as a form of active transportation that increases physical activity while at the same time
reducing traffic congestion, traffic-related air pollution and greenhouse gas emissions.
While at a population level the health benefits of exercise via cycling are estimated to
substantially exceed any health impacts related to air pollution exposure and injuries from
traffic accidents , cyclists are known to experience elevated exposures to traffic-related
air pollutants. Combined with exposure to elevated concentrations of air pollutants,
cyclists also are subject to substantially increased inhaled doses due to their level of
exertion and consequently increased inhalation rate. Therefore, given that cyclists
experience exposures to relatively high concentrations of traffic-related air pollutants and
that their inhalation of these pollutants is increased, it is important to evaluate the
potential health impacts of this scenario. Research on the potential health impacts related
to exercise (cycling) and urban air pollution exposure can help inform public communication
strategies related to air quality and its health impacts. In addition, as our previous work
suggests substantial variability in air pollution exposures to cyclists that is related to
the route type and the levels of traffic along cycling routes, there is potential for
transportation planners to promote increased cycling by enhancing infrastructure while at
the same time developing routes that also minimize exposure to air pollution. The cyclist
population is also interested in information regarding the air pollution exposures and
potential health impacts related to cycling.
The objective of this study is to investigate the relationship between traffic-related air
pollution exposure, and respiratory and cardiovascular health impacts in commuting cyclists.
Specifically, the investigators propose to:
1. determine commuting cyclists' exposure to traffic-related air pollutants (PM 2.5, PM10,
ultrafine particulate, black carbon) while cycling along two different bicycle routes
in the city of Vancouver;
2. estimate the pollutant dose received by each cyclist, and relate this to the health
effects observed; and
3. determine if there is a change in lung function, endothelial function, and C-reactive
protein level related to the level of air pollution exposure and dose
Status | Completed |
Enrollment | 38 |
Est. completion date | November 2011 |
Est. primary completion date | November 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 19 Years to 39 Years |
Eligibility |
Inclusion Criteria: - Age 19- 39 - male or female - able to bicycle comfortably on city streets for 1 hour Exclusion Criteria: - Smokers of any substance (smoking more than 1x every 2 weeks) - Must be of height to safely ride a test bike (<5'2", >6'5" ) - Diagnosed asthma or active allergy (hav fever) symptoms - Irregular menstrual cycle, pregnant, breastfeeding, non-monocyclic contraceptive medication or device - Taking medication for heart or lung condition - Answers yes to any questions on physical activity readiness questionnaire (PAR-Q) - requires pain medication daily - visual or hearing impairment that prevents safe cycling on streets with motor vehicles |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Canada | Air Pollution Exposure Lab, Vancouver General Hospital through the School of Population and Public Health, University of British Columbia | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Change in blood levels of C-reactive protein (a marker of systemic inflammation) | Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors | No | |
Other | Change in blood levels of Interleukin-6 (a marker of systemic inflammation) | Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors | No | |
Other | Change in blood levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG)(a marker of oxidative stress) | Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors | No | |
Primary | Change in endothelial function, as measured by peripheral arterial tonometry (EndoPAT) score of reactive hyperemia index (RHI) | Baseline (1 hour pre-expousre) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors | No | |
Secondary | Change in lung function (using spirometry to assess lung function values) | Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors | No |
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