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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01708356
Other study ID # H10-00902
Secondary ID H1008-111481/001
Status Completed
Phase N/A
First received October 9, 2012
Last updated October 15, 2012
Start date June 2010
Est. completion date November 2011

Study information

Verified date October 2012
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority Canada: Health Canada
Study type Interventional

Clinical Trial Summary

Introduction: Cycling is currently promoted at the municipal, provincial and national level as a form of active transportation that increases physical activity while at the same time reducing traffic congestion, traffic-related air pollution and greenhouse gas emissions. While at a population level the health benefits of exercise via cycling are estimated to substantially exceed any health impacts related to air pollution exposure and injuries from traffic accidents , cyclists are known to experience elevated exposures to traffic-related air pollutants. Combined with exposure to elevated concentrations of air pollutants, cyclists also are subject to substantially increased inhaled doses due to their level of exertion and consequently increased inhalation rate. Therefore, given that cyclists experience exposures to relatively high concentrations of traffic-related air pollutants and that their inhalation of these pollutants is increased, it is important to evaluate the potential health impacts of this scenario. Research on the potential health impacts related to exercise (cycling) and urban air pollution exposure can help inform public communication strategies related to air quality and its health impacts. In addition, as our previous work suggests substantial variability in air pollution exposures to cyclists that is related to the route type and the levels of traffic along cycling routes, there is potential for transportation planners to promote increased cycling by enhancing infrastructure while at the same time developing routes that also minimize exposure to air pollution. The cyclist population is also interested in information regarding the air pollution exposures and potential health impacts related to cycling.

The objective of this study is to investigate the relationship between traffic-related air pollution exposure, and respiratory and cardiovascular health impacts in commuting cyclists. Specifically, the investigators propose to:

1. determine commuting cyclists' exposure to traffic-related air pollutants (PM 2.5, PM10, ultrafine particulate, black carbon) while cycling along two different bicycle routes in the city of Vancouver;

2. estimate the pollutant dose received by each cyclist, and relate this to the health effects observed; and

3. determine if there is a change in lung function, endothelial function, and C-reactive protein level related to the level of air pollution exposure and dose


Recruitment information / eligibility

Status Completed
Enrollment 38
Est. completion date November 2011
Est. primary completion date November 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 19 Years to 39 Years
Eligibility Inclusion Criteria:

- Age 19- 39

- male or female

- able to bicycle comfortably on city streets for 1 hour

Exclusion Criteria:

- Smokers of any substance (smoking more than 1x every 2 weeks)

- Must be of height to safely ride a test bike (<5'2", >6'5" )

- Diagnosed asthma or active allergy (hav fever) symptoms

- Irregular menstrual cycle, pregnant, breastfeeding, non-monocyclic contraceptive medication or device

- Taking medication for heart or lung condition

- Answers yes to any questions on physical activity readiness questionnaire (PAR-Q)

- requires pain medication daily

- visual or hearing impairment that prevents safe cycling on streets with motor vehicles

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention


Related Conditions & MeSH terms


Intervention

Behavioral:
Cycling on a residential route


Locations

Country Name City State
Canada Air Pollution Exposure Lab, Vancouver General Hospital through the School of Population and Public Health, University of British Columbia Vancouver British Columbia

Sponsors (1)

Lead Sponsor Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Other Change in blood levels of C-reactive protein (a marker of systemic inflammation) Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors No
Other Change in blood levels of Interleukin-6 (a marker of systemic inflammation) Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors No
Other Change in blood levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG)(a marker of oxidative stress) Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors No
Primary Change in endothelial function, as measured by peripheral arterial tonometry (EndoPAT) score of reactive hyperemia index (RHI) Baseline (1 hour pre-expousre) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors No
Secondary Change in lung function (using spirometry to assess lung function values) Baseline (1 hour pre-exposure) and 1 hour post- exposure (plus or minus 30 minutes) to a bicycle ride in an urban environment outdoors No
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