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Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance

Endometriosis Clinical Trial

Official title:
Prospective Clinical Study of the Relationship Between Cancer Driving Mutations Found in Endometriotic Implants and the Development of Progesterone Resistance

Clinical Trial Summary

This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.

Clinical Trial Description

Tissues from 100 patients with endometriosis will be analyzed with droplet digital PCR (ddPCR) targeted sequencing and responders (n=50) will be compared to non-responders (n=50) after controlling confounding factors. From a subset of the 100 cases, whole exome sequencing (WES) and Methylation-Specific PCR (MSP)-based methylation profiling on microdissected epithelium and stroma will be performed in matched eutopic and ectopic tissues from 20 patients with known cancer-associated mutations or 20 controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03756480
Study type Observational
Source Johns Hopkins University
Contact James Segars, MD, FACOG
Phone 410-614-2000
Email jsegars2@jhmi.edu
Status Recruiting
Phase
Start date October 1, 2020
Completion date October 1, 2026
View Details
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