Endometriosis Clinical Trial
Official title:
Influence of WNT4 VEZT FSHB and SIRT1 Genetic Polymorphisms in the Pathogenesis of Endometriosis: a Case Control Study of the Sardinian Population
NCT number | NCT02388854 |
Other study ID # | ENDOSNPs |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | September 1, 2019 |
Est. completion date | December 2021 |
Verified date | February 2021 |
Source | University of Cagliari |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Endometriosis, defined as the presence of endometrial tissue outside the uterine cavity, affects 6-10% of the general population of women in childbearing age. The pathogenesis of the disease is unknown. The purpose of this study is to evaluate the influence of certain polymorphisms of genes WNT4, VEZT, FSHB, known to be involved in molecular mechanisms associated with phenomena of proliferation and development of endometriotic lesions, and SIRT1, that based on metabolomics studies, could hypothetically have a role in the pathogenesis of the disease. The study focus on the Sardinian population, known to have unique genetic characteristics due to geographical isolation.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | December 2021 |
Est. primary completion date | June 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria (cases): - endometriosis diagnosis (clinic, ultrasound or histological) - women of Sardinian origin Inclusion Criteria (controls): - no signs of endometriosis - women of Sardinian origin Exclusion Criteria (cases and controls): - women of non-Sardinian origin - patients unable to provide written informed consent or to follow the procedures provided by the protocol |
Country | Name | City | State |
---|---|---|---|
Italy | University of Cagliari,Obstetrics and Gynecological Department, | Monserrato | Cagliari |
Lead Sponsor | Collaborator |
---|---|
University of Cagliari |
Italy,
Matalliotakis M, Zervou MI, Matalliotaki C, Rahmioglu N, Koumantakis G, Kalogiannidis I, Prapas I, Zondervan K, Spandidos DA, Matalliotakis I, Goulielmos GN. The role of gene polymorphisms in endometriosis. Mol Med Rep. 2017 Nov;16(5):5881-5886. doi: 10.3892/mmr.2017.7398. Epub 2017 Aug 29. — View Citation
Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM; iPSYCH-SSI-Broad Group, Yang J, Velez Edwards DR, Nyegaard M, Low SK, Zondervan KT, Missmer SA, D'Hooghe T, Montgomery GW, Chasman DI, Stefansson K, Tung JY, Nyholt DR. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. Nat Commun. 2017 May 24;8:15539. doi: 10.1038/ncomms15539. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Frequency of Single Nucleotide Polymorphisms of WNT4, VEZT, FSHB and SIRT1 in Sardinian women with and without endometriosis diagnosis | baseline |
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