Endometriosis Clinical Trial
Our previous results revealed that the expression of killer inhibitory receptors (KIRs) on
NK cells was decreased in eutopic endometrium in women with adenomyosis. It implies that the
formation of adenomyosis might be due to abnormal endometrial tissues, but not the aberrant
local immunological dysfunction in myometrium. In addition, in vitro coculture of
macrophages and endometrial stromal cells (ESC) increase the expression of IL-6 mRNA in ESC,
which might further enhance the proliferation of ESC and subsequently result in the
formation of ectopic endometrial implants in adenomyosis. Besides, another possible
mechanism is the abnormal apoptosis of ESC in adenomyosis. In endometriosis, apoptotic
endometrial cells were found to be decreased, which possibly accounts for the formation of
endometriosis. However, there have not been reports investigating the apoptosis of ESC in
adenomyosis.
In this study, we try to investigate apoptotic ESC with flow cytometry in women with and
without adenomyosis. Annexin V, bcl-2, and caspase-3 were measured to represent the degree
of apoptosis in ESC.
Eutopic endometrium was obtained and separated into single endometrial stromal cell (ESC) in
women with adenomyosis (study group) and without adenomyosis (control group).
Annexin V-PE, bcl-2-PE, and caspase-3-PE are stained, and flow cytometry is done to measure
the degree of apoptosis in ESC. On the other hand, another half of ESC are cultured for 24h,
and also Annexin V-PE, bcl-2-PE, and caspase-3-PE are stained, and flow cytometry is done.
;
Observational Model: Defined Population, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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|
Phase 3 | |
| Recruiting |
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A Study to Evaluate Safety and Efficacy of Elagolix in Patients With Moderate to Severe Endometriosis-Associated Pain
|
Phase 3 | |
| Completed |
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|
N/A | |
| Recruiting |
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Endometriosis Pain
|
||
| Completed |
NCT04665414 -
Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI
|
||
| Completed |
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Study of Real Clinical Practice to Evaluate the Effects of Oral Dydrogesterone for Treatment of Confirmed Endometriosis
|
||
| Recruiting |
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|
||
| Active, not recruiting |
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Ultrasound Evaluation of the Pelvis in Women With Suspected Endometriosis Scheduled for Laparoscopic Surgery
|
||
| Recruiting |
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The Influence of TAP Block in the Control of Postoperative Pain After Laparotomy for Gynecological Procedures
|
N/A | |
| Completed |
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Strategies of Self-management of Endometriosis Symptoms
|
||
| Completed |
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Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
|
N/A | |
| Withdrawn |
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|
||
| Not yet recruiting |
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|
||
| Active, not recruiting |
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|
N/A | |
| Completed |
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|
||
| Withdrawn |
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|
N/A | |
| Recruiting |
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|
N/A | |
| Active, not recruiting |
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Three Different Laparoscopic Approaches for Ovarian Endometrioma and the Effect on Ovarian Reserve
|
N/A | |
| Completed |
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GnRH-a on Angiogenesis of Endometriosis
|
N/A | |
| Completed |
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|
Phase 4 |