Endometrial Receptivity Clinical Trial
Official title:
Correlation Between Serum Progesterone Levels and the Endometrial Gene Expression Profile of 238 Genes Related With Endometrial Receptivity (Through Patented ERA Test), as Well as Correlation With Endometrial Progesterone Levels.
Since the implantation is related with endometrial receptivity, the patient specific plasma
progesterone concentration influences this pattern.
Following this hypothesis, the study establishes a correlation between the serum progesterone
measured on the day of the endometrial biopsy and the endometrial receptivity with the ERA
test.
In patients who have had problems of assisted reproduction it is essential to establish the
factors that contribute to the success of a cycle: correcting these factors means increasing
the possibility of the cycle culminating in pregnancy.
In patients with embryonic implantation failures, a prevalence of non-receptive endometrium
has been described after performing the ERA test of around 20%. On the other hand, a study
that shows embryonic generation values below a certain threshold (25th percentile), presents
a rate of evolutionary clinical gestation and lower embryo implantation.
It is logical to think that progesterone levels are lower than the state of endometrial
receptivity, since the hormone is responsible for the endothelial changes that prepare the
uterus for implantation. It is ERA. The result of this study is the result of the evaluation
of the lifetime of the endometrial biopsy is related to the result of the same.
If desired, the determination of the probability of the day of the transfer is predictive of
the pregnancy rate through the impact that the hormone has on the endometrial receptivity.
This would allow to decide in the same cycle, if the patient should be in a transfer to
another dimension, or should it defer to another cycle where obtain the optimal values of
progesterone.
Nowadays, there are no publications in the literature that have related the concentration of
progesterone with endometrial receptivity through ERA. This is the first prospective study
that analyzes this relationship.
The ERA test has been chosen for the evaluation of endometrial receptivity, which is a tool
that has been widely used and used in the usual clinical practice of our clinic.
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