Endometrial Polyp Clinical Trial
Official title:
Efficacy of Subcutaneous Progesterone in Premenopausal Woman With Endometrial Polyp: a Multicentric Randomized Control Trial
This prospective randomized study will compare the regression rates of women managed with watch-and-wait approach and of those treated with 3 cycles of luteal 25mg subcutaneous progesterone from 18 to 25 days of menstrual cycle
In premenopause, 25% of endometrial polyps regresses spontaneously in 1 year. According to
guidelines, given that most premenopausal polyps are not malignant, there is an option for
expectant approach with no surgical intervention. Studies on the efficacy of medical
treatments for endometrial polyps are also recommended by gynaecologic societies, with the
aim of finding cost-saving not invasive strategies to manage this common pathology. Up to
now, nobody has investigated the effect of progestin administration on polyps, but molecular
and clinical data suggest that the antiestrogenic effect of this hormone can be exploited to
increase and speed-up their regression rate. Our preliminary results on the effect of three
months of progesterone demonstrated a regression rate of 47,5% in women treated vs 12,5% in
those don't receiving treatment.
Accordingly, in this prospective randomized study we aim to compare the regression rates of
women managed with watch-and-wait approach and of those treated with 3 cycles of luteal 25mg
subcutaneous progesterone from 18 to 25 days of menstrual cycle
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00247923 -
Endometrial Polyps: Pathophysiology and Clinical Consequences
|
N/A | |
Not yet recruiting |
NCT06295510 -
Observational Study of the Association Between Food Intake and Endometrial Polyps
|
||
Recruiting |
NCT03207126 -
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?
|
N/A | |
Completed |
NCT04706000 -
Autophagy Markers in Endometrial Polyps
|
||
Completed |
NCT06316206 -
The Use of Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
|
Phase 4 | |
Completed |
NCT06316180 -
The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation
|
Phase 4 | |
Completed |
NCT06324851 -
The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
|
Phase 4 | |
Completed |
NCT06316219 -
The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation
|
Phase 4 | |
Completed |
NCT03790215 -
Dydrogesterone in the Treatment of Endometrial Polyps
|
Phase 4 | |
Recruiting |
NCT01637974 -
Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery
|
N/A | |
Completed |
NCT05337605 -
Hand Driven Versus Motor Driven Hysteroscopic Tissue Removal System for Polypectomy: Long-term Results
|
||
Completed |
NCT05337046 -
Hysteroscopic Tissue Removal System Versus Bipolar Resectoscopy for Polypectomy: Long-term Results
|