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Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer

Endometrial Neoplasms Clinical Trial

Official title:
A Prospective Study to Evaluate Online Adaptive Radiotherapy in Postoperative Treatment of Endometrial and Cervical With Reduced Margin

Clinical Trial Summary

Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for postoperative treatment of endometrial and cervical cancer. To explore the value of reduced margins in oART for postoperative treatment of endometrial and cervical cancer, we conducted a prospective clinical trial to determine the clinical efficacy and toxicity of reduced margins.

Clinical Trial Description

This is an investigator-initiated efficacious, single-center, open-label clinical trial study. This study hypothesizes that the use of reduced PTV margins in oART for postoperative treatment of endometrial and cervical cancer could decrease toxicity and achieve more accurate dosimetric coverage. A dose of 45 or 50.4 Gy is delivered to clinical target volume (CTV) with reduced margin oART. Patients receive cisplatin based concurrent chemotherapy. The primary endpoint is acute toxicity. The first 10 patients were included in the study that have demonstrated the feasibility of reducing the margin (ClinicalTrials.gov ID: NCT05682950). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05869123
Study type Interventional
Source Peking Union Medical College Hospital
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date October 20, 2022
Completion date March 3, 2025
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