Metformin for the Treatment of Endometrial Hyperplasia

Status Completed

Clinical Trial Summary

The purpose of this study is to see if metformin will be effective in making endometrial hyperplasia without atypia better by returning the tissue to a normal state.

Clinical Trial Description

This is a multi-institutional pilot clinical trial designed to estimate the response rate and safety of metformin for the treatment of simple and complex endometrial hyperplasia (EH) without atypia. Enrollment of patients will occur at UNC-Chapel Hill and Southern Pines Women's Health Center. Fifteen patients will be enrolled over the course of 1 year. Metformin will be initiated at 850 mg orally once daily, and titrated up to twice daily over a minimum of 1 months time. Treatment will last 12 weeks and then patients will undergo repeat endometrial biopsy to assess for regression or persistence of EH. ;

Study Design

Related Conditions & MeSH terms

Endometrial Hyperplasia
Endometrial Hyperplasia Without Atypia
Hyperplasia

Clinical Trial Details

NCT number	NCT01685762
Study type	Interventional
Source	UNC Lineberger Comprehensive Cancer Center
Contact
Status	Completed
Phase	Early Phase 1
Start date	January 10, 2013
Completion date	December 1, 2015

View Details

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