Endometrial Cancer Clinical Trial
Official title:
Evaluation of Doxil as First-Line Therapy of Advanced or Recurrent Endometrial Carcinoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of liposomal doxorubicin in treating
women who have recurrent, stage III, or stage IV endometrial cancer.
OBJECTIVES:
- Determine the antitumor activity and safety of doxorubicin HCl liposome in patients
with advanced or recurrent endometrial cancer.
- Determine the response rate, response duration, and overall survival of these patients
treated with this regimen.
OUTLINE: Patients receive doxorubicin HCl liposome IV over 1 hour. Courses repeat every 4
weeks in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 19-51 patients will be accrued for this study.
;
Primary Purpose: Treatment
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