Endometrial Cancer Clinical Trial
Official title:
A Phase II Study of Letrozole in Patients With Advanced or Recurrent Endometrial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of letrozole in treating women who have
recurrent or metastatic endometrial cancer.
OBJECTIVES: I. Determine the efficacy of letrozole, in terms of objective tumor response and
time to progression, in women with recurrent or metastatic endometrial cancer. II. Determine
the toxicity of letrozole in these patients. III. Determine the relationship between tumor
receptor status, histologic grade, tumor aromatase activity, and tumor response in these
patients.
OUTLINE: Patients receive an oral letrozole tablet daily. Treatment continues for patients
with complete or partial response until disease progression or unacceptable toxicity.
Patients with stable disease may discontinue therapy after 24 weeks. Patients are followed at
1 month and then every 3 months until death.
PROJECTED ACCRUAL: Up to 30 patients will be accrued for this study within 12-18 months.
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