Comparison of Antibacterial Efficacy of Three Final Irrigants

Status Completed

Clinical Trial Summary

This study was conducted to determine the antibacterial affect of three different solutions used as final irrigant during endodontic therapy. The investigator's objective was to compare the antibacterial affect of relatively new final irrigant QMix with EDTA and Qmix with EDTA+CHX by evaluating the bacteriological status of the root canal before and after use of the final irrigant.

Clinical Trial Description

The aim of this clinical trial is to compare the antibacterial efficacy of Qmix, to 17% EDTA+ Chlorhexidine and 17% EDTA, used as final irrigants, during endodontic procedure.

Endodontic treatment was carried out on 90 necrosed teeth of patients under rubber dam isolation and strict sterilization protocol. The teeth were divided into three groups; A, B and C depending on the type of final irrigant to be used. The chemo-mechanical preparation of all the 90 samples was carried out using ProTaper Universal (Dentsply) File system, and 3% sodium Hypochlorite. All the samples from each group were then irrigated according to the final rinse protocol (FRP). Group A was irrigated with Qmix; Group B with 17% EDTA + 2% Chlorhexidine and Group C (Control group) 17% EDTA.

Three bacteriologic samples were taken during the procedure from each root canal under study in all three groups, using sterile paper points. Sample A was collected after access cavity opening and negotiation of the canal but before chemo-mechanical preparation. Sample B was taken after chemo-mechanical preparation but before the use of the final irrigant. Sample C was collected after the use of final irrigation solution. The samples were collected with sterile paper points and were then transferred to microbiology laboratory in microtubes containing Brain Heart Infusion (BHI) broth within 2 hours of sample collection for obtaining the colony forming unit (CFU) counts. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03853200
Study type	Interventional
Source	Dow University of Health Sciences
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	April 3, 2017
Completion date	February 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05338671` - Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment	Phase 4
Withdrawn	`NCT03502135` - Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment	Phase 4
Recruiting	`NCT04528979` - Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer	N/A
Recruiting	`NCT04527705` - Outcome of Endodontic Retreatment in One or Two Visits	N/A
Completed	`NCT04102293` - Time Efficiency and Obturation Quality of Rotary Versus Manual in Primary Teeth	N/A
Completed	`NCT03635515` - Occurrence of Post-op Pain Following Gentlewave	N/A
Completed	`NCT04211519` - Analysis of Bacterial Microbiome of Endodontically Infected Primary and Permanent Teeth	N/A
Recruiting	`NCT05959629` - Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection	N/A
Recruiting	`NCT04471558` - Effect of Music on Young Practitioner's Stress During Endodontic Treatment
Active, not recruiting	`NCT05555043` - Comparison of Clinical Outcomes Between GentleWave® and Biolase®	N/A
Completed	`NCT04109417` - Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery	N/A
Completed	`NCT04462731` - Post-endodontic Pain Survey	N/A
Not yet recruiting	`NCT05935306` - Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery	N/A
Not yet recruiting	`NCT05681754` - Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF	N/A
Active, not recruiting	`NCT05612451` - Outcome of Regenerative Endodontic Procedures	N/A
Completed	`NCT03042377` - Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases	Phase 4
Completed	`NCT04617301` - Volumetric Analysis of Resorption Types on CBCT
Not yet recruiting	`NCT06439212` - the Efficacy of Ginger Powder as an Analgesic for Intraoperative and Post- Endodontic Pain Management	Phase 3
Recruiting	`NCT03451435` - N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization	Early Phase 1
Completed	`NCT04481945` - Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles	Phase 4