Oral Glucose Stimulation in Normal-weight and Obese Volunteers

Endocrine System Diseases Clinical Trial

Official title:

Oral Glucose in Normal-weight and Obese Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01875575
• Other study ID #: EKBB 08/11
• Status: Completed
• Phase: N/A
• First received: May 8, 2013
• Last updated: June 11, 2013
• Start date: February 2013
• Est. completion date: April 2013

Study information

• Verified date: June 2013
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: April 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of > 30

• Normal eating habits

• Age 18-40 years

• Stable body weight for at least three months

Exclusion Criteria:

• Smoking

• Substance abuse

• Regular intake of medications (except for oral contraceptives)

• Medical or psychiatric illness

• Any abnormality detected during the screening procedure

• history of gastrointestinal disorders

• food allergies

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Endocrine System Diseases

Intervention

Dietary Supplement:
• Placebo

• Glucose 25g

• Glucose 10g

Locations

Country	Name	City	State
Switzerland	University Hospital Basel	Basel

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of different oral glucose loads on secretion of satiation hormones	Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured	240min.	No
Secondary	Effect of different oral glucose loads on gastric emptying	measured by C13 breath test	240min.	No