Incremental Hemodialysis: The TwoPlus Trial

Status Recruiting

Clinical Trial Summary

This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study will enroll 350 patients on chronic hemodialysis and 140 caregivers of enrolled patients. Patients will be randomized in 1:1 ratio to either incremental start hemodialysis or conventional hemodialysis. Caregivers will be followed along with patients for an average period of 2 years post randomization.

Clinical Trial Description

This study will analyze the effects of differentiated care with individualized hemodialysis on patient health related quality of life, fatigue, employment, and caregiver burden in patients with Kidney dysfunction requiring dialysis (KDRD) and appreciable kidney function. This study will compare the outcomes in survival, hospitalization, preservation of the kidney function and quality of life between hemodialysis tailored to each patient needs (incremental) and conventional hemodialysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05828823
Study type	Interventional
Source	Wake Forest University Health Sciences
Contact	Denisse A Funes
Phone	336-716-8671
Email	dfunes@wakehealth.edu
Status	Recruiting
Phase	N/A
Start date	February 26, 2024
Completion date	March 2028

View Details

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