Encephalitis Clinical Trial
Official title:
Pharmacokinetic Study of AVI-4065 in Cerebral Spinal Fluid Among Healthy Adult Males Following Subcutaneous Administration
AVI-4020 Injection, a phosphorodiamidate Morpholino oligomer (PMO), was found to cross the blood-brain barrier during a study of patients with presumptive West Nile virus disease. AVI-4065, which was designed to target HCV, is also a PMO; its ability to cross the blood-brain barrier is unknown. In this study, a single dose of AVI-4065 will be subcutaneously injected, and samples collected to determine if this drug crosses the blood-brain barrier. If it does, then additional investigations could be performed in people with severe forms of HCV disease in which the brain is affected.
AVI-4020 Injection, a phosphorodiamidate Morpholino oligomer (PMO), was found to cross the
blood-brain barrier during a study of patients with presumptive West Nile virus disease.
AVI-4065, which was designed to target HCV, is also a PMO; its ability to cross the
blood-brain barrier is unknown. As the incidence of HCV disease has grown, the knowledge
base of this disease has likewise increased.
Encephalopathy is a recognized consequence in some patients with HCV infection. In this
study, a single dose of AVI-4065 will be subcutaneously injected, and samples collected to
determine if this drug crosses the blood-brain barrier. If it does, then additional
investigations could be performed in people with HCV disease in which the brain is affected.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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