Emergency Service, Hospital Clinical Trial
Official title:
Is Mathematical Arterialized Peripheral Venous Blood Gas Reliable Compared to Arterial Blood Gas? - a Clinical Validation Study
Verified date | October 2017 |
Source | Aalborg University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Objective: Arterial blood gas (ABG) analysis is essential in the clinical assessment of
potential acutely ill patients. Venous to arterial conversion (v-TAC), a mathematical method,
has recently been developed to convert peripheral venous blood gas (VBG) values to
arterialized VBG (aVBG) values. The aim of this study was to test the reliability of aVBG
compared to ABG in an emergency department (ED) setting.
Method: Twenty ED patients were included in this study. ABG and three aVBG samples were
collected from each patient. The aVBG samples were processed in three different ways for
comparison: aVBG1 was held steady and analysed within 5 minutes; aVBG2 was tilted in 5
minutes and analysed within 7 minutes; aVBG3 was held steady and analysed after 15 minutes.
All VBG samples were arterialized using the v-TAC method. ABG and aVBG samples were compared
using Lin's Concordance Correlation Coefficient (CCC) and Bland-Altman's analysis.
Status | Completed |
Enrollment | 30 |
Est. completion date | October 1, 2017 |
Est. primary completion date | January 30, 2016 |
Accepts healthy volunteers | |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Admission to the emergency department. - Need for ABG for respiratory or metabolic assessment. Exclusion Criteria: - Circulatory unstable patients (systolic blood pressure < 90mmHg og heart rate <50beats/min or >110beats/min). |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Aalborg University | Center for Clinical Research, North Denmark Regional Hospital, Department of Anesthesiology, North Denmark Regional Hospital |
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* Note: There are 19 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lin's Concordance correlation coefficient | Comparison of venous pH between glass and syringe samples. | 1 day | |
Primary | Lin's Concordance correlation coefficient | Comparison of venous pCO2 (Unit of Measurement: kilopascal) between glass and syringe samples. | 1 day | |
Primary | Lin's Concordance correlation coefficient | Comparison of venous pO2 (Unit of Measurement: kilopascal) between glass and syringe samples. | 1 day | |
Primary | Bland and Altman plot | Comparison of venous pH between glass and syringe samples. | 1 day | |
Primary | Bland and Altman plot | Comparison of venous pCO2 (Unit of Measurement: kilopascal) between glass and syringe samples. | 1 day | |
Primary | Bland and Altman plot | Comparison of venous pO2 (Unit of Measurement: kilopascal) between glass and syringe samples. | 1 day | |
Primary | Lin's Concordance correlation coefficient | Comparison of pH between aVBG and ABG. | 1 day | |
Primary | Lin's Concordance correlation coefficient | Comparison of pCO2 (Unit of Measurement: kilopascal) between aVBG and ABG. | 1 day | |
Primary | Lin's Concordance correlation coefficient | Comparison of pO2 (Unit of Measurement: kilopascal) between aVBG and ABG. | 1 day | |
Primary | Bland and Altman plot | Comparison of pH between aVBG and ABG. | 1 day | |
Primary | Bland and Altman plot | Comparison of pCO2 (Unit of Measurement: kilopascal) between aVBG and ABG. | 1 day | |
Primary | Bland and Altman plot | Comparison of pO2 (Unit of Measurement: kilopascal) between aVBG and ABG. | 1 day | |
Secondary | Hemoglobin concentration | Comparison of venous blood hemoglobin (Unit of Measurement: mmol/L) between glass and syringe blood. | 1 day |
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