Clinical Trials Logo

Clinical Trial Summary

While DOACs are increasing in use in the EGS patient population, the risk of bleeding and the reversal of these agents to reduce hemorrhage is still evolving. Given the paucity of data regarding the impact of DOACs in this patient population, it becomes empiric to identify bleeding patterns and outcomes in the EGS population taking DOACs. We hypothesize that patients taking a DOAC will have a higher bleeding incidence and need for an unplanned intervention secondary to hemorrhage in EGS patients undergoing an urgent or emergent operation when compared to patients taking warfarin and antiplatelets.


Clinical Trial Description

Emergency general surgery (EGS) represents illnesses of diverse pathology with urgent/emergent treatment needs being the common denominator.A characteristic feature of EGS is its limitation in patient preparation. It is difficult and often impossible to eliminate certain patient dependent factors to reduce the operative risk. It has been reported that the annual case rate in the EGS population is (1,290 per 100,000) higher than the sum of all cancer diagnoses. The EGS burden is substantial and continues to increase. The elderly patient population represents 48% of the overall EGS population. With the increase in the prevalence of atherosclerotic disease in the elderly there has been an increase in the use of antiplatelets and anticoagulants. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04216394
Study type Observational
Source Methodist Health System
Contact
Status Completed
Phase
Start date October 31, 2019
Completion date November 13, 2020

See also
  Status Clinical Trial Phase
Terminated NCT06118359 - Development and Pilot Testing the SITe Intervention N/A
Completed NCT04419571 - Outcomes in Emergency Laparotomies During COVID-19 Pandemic
Not yet recruiting NCT06043414 - Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT N/A
Completed NCT05664360 - Incidence and Outcomes of Emergency Department Patients Requiring Emergency General Surgery