Electrical Stimulation Clinical Trial
Official title:
Influence of Electrode Positioning and Current Type on Muscle Fatigability, Force Generation, Perceived Discomfort and Neuromuscular Adaptations Induced by Neuromuscular Electric Stimulation: Implications on Rehabilitation
Introduction: Neuromuscular electrical stimulation (NMES) has the purpose of generating muscle contractions to minimize muscular atrophy and to improve neuromuscular performance. NMES has been performed using monophasic or biphasic currents, applied over a nerve trunk or muscle belly, and both can generate contractions by the peripheral and central nervous system. Pulse width (wide or narrow) is an essential parameter for NMES. Although NMES studies using wide pulses have been performed with monophasic currents, it is known that this current induces discomfort during NMES. Therefore, it is necessary to analyze if biphasic currents have the same effect as monophasic currents using the same parameters. Objectives: To compare the effects of NMES with narrow and wide pulse widths associated with monophasic and biphasic currents, applied over a tibial nerve and triceps surae muscles in healthy individuals in terms of muscle fatigue, central and peripheral contribution, voluntary and evoked force and sensory discomfort. Methods: A crossover, experimental controlled and randomized study will be developed with healthy male and female (age: 18-45 years). The following dependent variables will be: amplitude of H-reflex and M-wave (single and double pulses), voluntary and evoked triceps surae muscles torque, fatigability (force time integral), perceived discomfort and neuromuscular adaptations. The independent variables will be related to current phase, pulse width and location of electrical stimulation electrodes. There will be a familiarization session followed by 9 sessions with 7 rest days between them (10 weeks). Data will be reported as mean and standard deviation (± SD). Parametric tests will be used for the normally distributed data (Shapiro-Wilk test) that show homogeneous variations (Levene test). A repeated measure mixed-model ANOVA will be performed and, in the case of major effects or significant interactions, the Tukey post-hoc test will be applied. In addition, the power and size of the effect (reported as partial eta square, partial η2) will be calculated. The significance threshold will be set at p <0.05 for all procedures. Expected results: Biphasic currents will be more comfortable and will generate less muscle fatigue when compared to monophasic currents. There will be less fatigue and greater central contribution when wider pulse currents will be applied over a nerve trunk concerning the application with a wide pulse over a muscle belly.
This is a randomized controlled trial, a crossover study, with healthy male and female participants. The procedures will take place in 10 distinct visits for a 7-day interval. The following visit in the lab will be: - Familiarization session. - Monophasic Current (100 Hz) with 1ms pulse width applied to the Tibial Nerve; - Biphasic current (100 Hz) with pulse width 0.5ms applied to the Tibial Nerve; - Biphasic current (100 Hz) with 1ms pulse width applied to the Tibial Nerve; - Biphasic current (100 Hz) with 2ms pulse width applied to the Tibial Nerve; - Monophasic (100 Hz) with 1ms pulse width applied to the Triceps Surae Muscle Belly; - Biphasic current (100 Hz) with pulse width 0.5ms applied to the Triceps Surae muscle Belly; - Biphasic current (100 Hz) with 1ms pulse width applied to the Triceps Surae Muscle Belly; - Biphasic current (100 Hz) with 2ms pulse width applied to the Triceps Surae Muscle Belly; - Biphasic current (25 Hz) with 0.5ms pulse width applied to the Triceps Surae Muscle Belly. The dependent variables will be: - Muscle fatigability; - Central and peripheral contribution (with H-reflex and M-wave amplitude analysis); - Maximum voluntary isometric contraction; - Force production for plantar flexion evoked by NMES; - Perceived discomfort. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT02734719 -
Increasing Bone Density by Application of Surface Electrical Stimulation
|
N/A | |
Completed |
NCT04884932 -
Percutaneous High Frequency Alternating Current Stimulation in Healthy Volunteers With 30kHz
|
N/A | |
Not yet recruiting |
NCT05905406 -
Effect of Femoral Quadriceps Muscle Length on Fatigue Induced by Neuromuscular Electrical Stimulation
|
N/A | |
Completed |
NCT04346719 -
Percutaneous High Frequency Alternating Current Stimulation in Healthy Volunteers
|
N/A | |
Completed |
NCT04389307 -
Intravaginal Electrical Stimulation in Idiopathic Overactive Bladder
|
N/A | |
Completed |
NCT04727983 -
Effects of External Neuromuscular Electrical Stimulation in Women With Urgency Urinary Incontinence
|
N/A | |
Recruiting |
NCT05236140 -
Electrical Stimulation in Men With Urinary Incontinence After Radical Prostatectomy
|
N/A | |
Recruiting |
NCT01820598 -
Phase II Study of Neuromuscular Electrical Multisite System on Cardiovascular Effects in Severe Obese Patients
|
N/A | |
Completed |
NCT04008589 -
Non-invasive Current Stimulation for Restoration of Vision
|
Phase 1/Phase 2 | |
Completed |
NCT04662229 -
Efficacy of Eco-guided PENS on Handgrip Strength
|
N/A | |
Enrolling by invitation |
NCT04010994 -
Treatment of Patients With Optic Nerve Damage Patients Using Electrostimulation
|
Phase 1/Phase 2 | |
Completed |
NCT04792125 -
Effect of External Electrical Stimulation and Pelvic Floor Muscle Training
|
N/A | |
Completed |
NCT05879939 -
Transcutaneous Repetitive Phrenic Nerve Stimulation in Healthy Adults
|
||
Completed |
NCT03822221 -
Angles of Knee and Hip Joints for Optimization of Neuromuscular Electrical Stimulation of the Quadriceps Femoris Muscle
|
N/A | |
Suspended |
NCT03905772 -
Neuromuscular Adaptations After Training in the Muscle Belly of Triceps Surae
|
N/A | |
Recruiting |
NCT05395715 -
Conditioning Electrical Stimulation to Improve Outcomes in Cubital Tunnel Syndrome
|
N/A | |
Completed |
NCT06048471 -
High Tone Therapy for Chemotherapy Induced Neuropathy
|
N/A |