Elective Major Abdominal Surgery Clinical Trial
Official title:
The Effects of Intravenous Lidocaine Infusion During and After Major Abdominal Pediatric Surgery. A Randomized Double-blinded Study
In this study, the investigators hypothesized that perioperative i.v. infusion of lidocaine in major abdominal pediatric surgery, may have a beneficial effect on hemodynamic and hormonal responses. Also, it could decrease the hospital stay, opioid requirement and hasten return of bowel function.
The inflammatory response after major abdominal surgery is of great importance for patients,
physicians and perioperative medicine1. Perioperative excessive stimulation of the
inflammatory and hemostatic systems may result in development of postoperative ileus,
ischemia-reperfusion syndromes, hypercoagulation syndromes (e.g. deep venous thrombosis) and
pain excessive inflammatory response such as impaired gastrointestinal motility, so
modulation of inflammatory responses may decrease severity of such complications 2,3.
Intravenous lidocaine, a local anesthetic, has been shown to improve postoperative
analgesia, reduce postoperative opioid requirements, accelerate postoperative recovery of
bowel function, attenuate postoperative fatigue, reduced the duration of hospitalization,
and facilitate acute rehabilitation in patients undergoing laparoscopic abdominal surgery 4.
Administration of local anesthetics to epidural space has analgesic effect, blunt stress
response; provide rapid mobilization, early extubation with rapid recovery of bowel function
5. However, insertion of an epidural catheter carries risks especially in pediatric
populations. So, systemic lidocaine may become another strategy for improving perioperative
outcome which is safe and effective2.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
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Completed |
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N/A | |
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