Prevention and Treatment of Perioperative Lung Injury in Elderly Patients

Elderly Patients Clinical Trial

Official title:

Prevention and Treatment of Perioperative Lung Injury in Elderly Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05701449
• Other study ID #: PPCS192023
• Status: Not yet recruiting
• Start date: January 2023
• Est. completion date: December 2023

Study information

• Verified date: January 2023
• Source: Wuhan Union Hospital, China
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims to verify the prediction model of postoperative pulmonary complications by collecting clinical information on elderly patients. In addition, the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model was compared.

Description:

More than 300 million major operations are performed worldwide each year, and older patients account for about a third of elective operations. Compared with young people, the elderly are more prone to postoperative complications due to age-related degeneration of the physiological functions of various organs and tissues. Postoperative pulmonary complications, including pneumonia, atelectasis, and respiratory failure, are common. Even mild pulmonary complications can lead to the prolonged hospital stay and increased postoperative mortality.

Although there have been many studies on postoperative lung complications, there have been few studies on elderly patients. In our country, the real incidence data of elderly patients after a perioperative period of pulmonary complications, the lack of effective prevention, intervention measures, and targeted prevention and treatment technology, these reasons lead to the clinical diagnosis and treatment of elderly patients after a perioperative period of pulmonary complications are very difficult. Therefore, the research team intends to verify the established prediction model of postoperative pulmonary complications and compare the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 5000
• Est. completion date: December 2023
• Est. primary completion date: December 2023
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

1. Age 65 years or older

2. receiving invasive ventilation during general anesthesia for surgery

Exclusion Criteria:

1. preoperative mechanical ventilation

2. procedures related to a previous surgical complication

3. a second operation after surgery within one week

4. organ transplantation

5. discharged within 24 hours after surgery

Related Conditions & MeSH terms

• Elderly Patients
• Lung Injury
• Postoperative Pulmonary Complications

Locations

Country	Name	City	State
n/a

Sponsors (20)

Lead Sponsor

Collaborator

Wuhan Union Hospital, China

China-Japan Friendship Hospital, Chinese PLA General Hospital, Danjiangkou First Hospital, Dongfeng General Hospital of Chinese Medicine, First Affiliated Hospital of Guangxi Medical University, First Affiliated Hospital of Zhejiang University, Qinghai People's Hospital, Shanxi Cardiovascular Hospital, Shiyan City Renmin Hospital, Shiyan Integrated Traditional and Western Medicine Hospital, Shiyan Taihe Hospital, Shiyan Traditional Chinese Medicine Hospital, Suizhou Central Hospital, Wuhan No.1 Hospital, Xiangyang Central Hospital, Xiangyang No.1 People's Hospital, Yunxi Renmin Hospital, Yunyang Renmin Hospital, Zhuxi Renmin Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative pulmonary complications		within one week after surgery
Secondary	Length of postoperative hospital stay		6 weeks after surgery
Secondary	Postoperative Death		6 weeks after surgery