Elderly ; Moderate Risk Surgery Clinical Trial
Official title:
Impact of Tight Intraoperative Blood Pressure and Depth of Anesthesia Control on the Incidence of Postoperative Cognitive Impairment in Elderly Patients
The aim of this study is to demonstrate that in elderly and frail patients, a narrower control of intraoperative blood pressure (BP) by the use of a continuous and noninvasive BP monitoring, coupled with an adequate depth of anesthesia, will reduce the incidence of postoperative cognitive impairment and the hospital length of stay.
Postoperative cognitive impairment (delirium and cognitive dysfunction) are frequent and
feared complications in the elderly; they increase the postoperative morbidity and mortality,
worsen the cognitive and functional outcome with loss of independence and increase the
hospitalization length and costs . However, the etiology of these postoperative cognitive
impairment, although probably multifactorial, remains unclear and strongly debated.
The investigators hypothesize that excessive anesthesia depths associated with intraoperative
hypotension may play a critical role in the pathogenesis of cognitive impairment following
surgery.
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