Elderly Men Clinical Trial
Official title:
Determination of the Tolerable Upper Intake Level (UL) of Leucine in Healthy Elderly Men (70-75 Yrs)
Amino acid are the building blocks of the body's protein. Some amino acids, including
leucine, cannot be made in the body and must be obtained from diet, these are called
essential. With increase in age the body's muscle mass decrease and studies have suggested
that dietary supplementation of leucine may have potential health benefits in elderly in
regards to prevention of age related loss of lean muscle mass, and thus may help improve the
quality of life in elderly.
Currently, a safe upper dietary intake level of leucine has not been established for healthy
elderly. Prior to exploring whether leucine supplementation will prevent or decrease loss of
lean muscle mass in elderly we propose to identify the upper intake of leucine in healthy
elderly.
The purpose of this study is to determine the tolerable upper intake level (UL) of leucine in
healthy elderly men (70 - 75 yrs)
The investigators hypothesize that with a careful graded stepwise increase in leucine intake
in elderly men, above the Estimated Average Requirement (EAR - 50 mg/kg/d), the body's
ability to oxidize/dispose of excess amino acids will reach a maximum. With increased leucine
intakes we hypothesize an increase in plasma ammonia concentrations and increases in plasma
leucine and urinary leucine excretion.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03287284 -
Phototherapy in Association to Resistance Training in the Elderly: the Effect on Muscle Strength, Muscle Mass and Functional Capacity
|
N/A |