Effects Toxics Clinical Trial
Official title:
The Effect and Frequency of Helicobacter Pylori Infection in Primary Immune Thrombocytopenic Patients Not Respond on Steroid Therapy.
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count
(i.e less than 100.000) . In ITP, platelet surface membrane proteins become antigenic for
unknown reasons , leading to stimulation of the immune system , autoantibody production, and
platelet destruction In recent years ,the list of etiologies of ITP has been steadily
increasing, so the term "idiopathic" is becoming obsolete, increasingly replaced by
"immune"TP .
Treatment of ITP may be conceptually divided into rescue therapy and maintenance therapy .
the terminology of corticosteroid-dependence means The need for ongoing or repeated doses
administration of corticosteroids for at least 2 months to maintain a platelet count at or
above 30 _ 109/L and/or to avoid bleeding. So, patients with corticosteroid dependence are
considered non responders
• Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet
count (i.e less than 100.000) . In ITP, platelet surface membrane proteins become antigenic
for unknown reasons , leading to stimulation of the immune system , autoantibody production,
and platelet destruction In recent years ,the list of etiologies of ITP has been steadily
increasing, so the term "idiopathic" is becoming obsolete, increasingly replaced by
"immune"TP.
Treatment of ITP may be conceptually divided into rescue therapy and maintenance therapy.
the terminology of corticosteroid-dependence means The need for ongoing or repeated doses
administration of corticosteroids for at least 2 months to maintain a platelet count at or
above 30 _ 109/L and/or to avoid bleeding. So, patients with corticosteroid dependence are
considered non responders The recent entry of Helicobacter pylori to the growing list of
etiologies of itp has stirred much interest. . The relationship between H pylori infection
and immune thrombocytopenia (ITP) is less clear .
However, among patients with H.pylori-associated ITP, a significant percentage achieve
lasting remission after eradication of H.pylori .
H.pylori can be readily detected by non invasive methods, the C-urea breath test and antigen
detection in stools are considered to be the most accurate, with both sensitivity and
specificity in the range of 90% to 95% .
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