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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01780376
Other study ID # BEAH FTR-8
Secondary ID
Status Completed
Phase N/A
First received January 28, 2013
Last updated June 18, 2015
Start date January 2013
Est. completion date February 2013

Study information

Verified date June 2015
Source Bagcilar Training and Research Hospital
Contact n/a
Is FDA regulated No
Health authority Turkey: Ministry of Health
Study type Interventional

Clinical Trial Summary

Whole Body Vibration (WBV) applies thrust force in opposite direction to gravity to body.This mechanical stimulation induces reflex muscular activity. Tonic vibration reflex (TVR) is most commonly cited mechanism to explain WBV-induced reflex muscular activity (WBV-IRMA), although there is no conclusive evidence that TVR occurs. The bone myoregulation reflex is another neurologic mechanism used to explain the effects of vibration on muscular performance.

Investigators hypothesized that latency of WBV-IRMA is different from latency of TVR. Primary aim of this study is to determine latency of WBV-IRMA. Secondary aim is to investigate whether WBV-IRMA is explained with TVR.

Twenty healthy young adult men are planned to include in this study. Participants will stand upright with their knees locked during WBV. PowerPlate Pro5 will be used for WBV. WBV with high amplitude at 25,30,35,40,45 and 50 Hz will be applied. Surface electrodes will be placed on both the soleus muscles. To measure TVR latency, piezo-electric accelerometer will be placed on the achilles tendon and this achilles tendon will be stimulated with spring based mechanical reflex hammer. Our pilot study was showed that motor unit potentials (MUAP) occurred in a 1:1 response with vibration. After confirmation of this finding, WBV-IRMA latency will be measured in the present study. To measure WBV-IRMA latency, piezo-electric force sensor will be placed between heel and WBV platform. Exact moment of initial strike of heel when thrust force expressed by WBV begin to be transferred to body will be determined. The time between moment of the initial strike and corresponding MUAP is defined as "WBV-IRMA latency". Piezo-electric stretch sensor will be placed between knee and malleol to simulate muscle spindle. The reflex muscle activity of soleus muscles will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.

This project is planed to be completed in 1 months.


Description:

Whole-body vibration (WBV), as a method of exercise training, is becoming increasingly popular in physical therapy, rehabilitation, and professional sports, and is increasingly used in beauty and wellness applications due to its beneficial effects on the neuromusculoskeletal system. These benefits include improved strength, power, flexibility, jump height, and balance. However, little is known about the physiological mechanisms underlying the effects of WBV on muscular performance, although the presence of reflex muscle activity during WBV has been shown. Tonic vibration reflex is the most commonly cited mechanism to explain the effects of WBV on muscular performance, although there is no conclusive evidence that TVR occurs. Studies have reported that direct vibration applied to a muscle or tendon stimulates muscle spindles, thereby causing a tonic vibration reflex to occur. As highlighted by these studies, muscle spindle discharges are sent to the spinal cord through Group Ia afferents during muscle or tendon vibration. There, they activate motoneurones that cause the muscle to contract. However, it has been reported that the sensitivity of the muscle spindle decreases or does not increase and that presynaptic inhibition occurs in Group Ia afferent fibers with vibration.

The bone myoregulation reflex (BMR) is another neurologic mechanism used to explain the effects of vibration on muscular performance. BMR is a reflex mechanism in which osteocytes exposed to cyclic mechanical loading induce muscle activity. Osteocytes embedded in the bone matrix are interconnected by numerous dendritic processes, forming a wide, mechanosensitive cellular network. Osteocytes exposed to cyclic mechanical loading send mechanical input signals to the central nervous system, influencing the neuronal regulation of muscle activity.

Investigators hypothesized that latency of WBV-IRMA is different from latency of TVR. Primary aim of this study is to determine latency of WBV-IRMA. Secondary aim is to investigate whether WBV-IRMA is explained with TVR.

Twenty healthy young adult men are planned to include in this study. Participants will stand upright with their knees locked during WBV. PowerPlate Pro5 will be used for WBV. WBV with high amplitude at 25,30,35,40,45 and 50 Hz will be applied. Surface electrodes will be placed on both the soleus muscles. To measure TVR latency, piezo-electric accelerometer will be placed on the achilles tendon and this achilles tendon will be stimulated with spring based mechanical reflex hammer. Our pilot study was showed that motor unit potentials (MUAP) occurred in a 1:1 response with vibration. After confirmation of this finding, WBV-IRMA latency will be measured in the present study. To measure WBV-IRMA latency, piezo-electric force sensor will be placed between heel and WBV platform. Exact moment of initial strike of heel when thrust force expressed by WBV begin to be transferred to body will be determined. The time between moment of the initial strike and corresponding MUAP is defined as "WBV-IRMA latency". Piezo-electric stretch sensor will be placed between knee and malleol to simulate muscle spindle. The reflex muscle activity of soleus muscles will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.

This project is planed to be completed in 1 months.


Recruitment information / eligibility

Status Completed
Enrollment 20
Est. completion date February 2013
Est. primary completion date January 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 20 Years to 45 Years
Eligibility Inclusion Criteria:

- Healthy men

- Men with ages varying between 20 and 45 years

- Right-handed men

Exclusion Criteria:

- Bone, muscle/tendon, joint, vascular, dermatologic diseases in lower extremities and spine

- Medication that could affect the musculoskeletal system

- Postural abnormalities (scoliosis, kyphosis, etc)

- Systemic diseases

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science


Related Conditions & MeSH terms


Intervention

Procedure:
whole-body vibration (WBV)
whole-body vibration (4 mm amplitude, 25,30,35,40,45,50 Hz)

Locations

Country Name City State
Turkey Bagcilar TRH Istanbul

Sponsors (1)

Lead Sponsor Collaborator
Bagcilar Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary latency of reflex muscle activity Whole-body vibration induced reflex muscle activity latency 1 month No
See also
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Not yet recruiting NCT03016286 - Bone Myoregulation Reflex & Presynaptic Ia Inhibition N/A
Completed NCT02886819 - Whole-body Vibration Induces a Short or Long Latency Muscular Reflex N/A
Completed NCT01419782 - Effects of Unilateral WBV on Muscleactivity of Contralateral Hip Adductor N/A
Completed NCT01310348 - Effect of Bone on Vibration-Induced Muscle Strength Gain N/A
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