EBV Clinical Trial
Official title:
Comparison of Abbott Architect®, Siemens Immulite®, and Diasorin Liaison® for Determination of Epstein-Barr Virus Serological Diagnosis
This study compared the performance of three automated immunoassays, Architect (Abbott), Immulite (Siemens) and Liaison (Diasorin), for Epstein-Barr virus (EBV) serology. Ninety-one serum samples collected in Amiens University Hospital were analyzed for the presence of Viral Capsid Antigen (VCA) IgG and IgM and Epstein-Barr Nuclear Antigen (EBNA) IgG. The agreement between the three assays was calculated for each marker individually and for determination of the EBV profile, based on interpretation of the combination of these three EBV markers.
This retrospective study was conducted on 91 samples collected between 2014 and 2015 for
which EBV diagnosis was requested. The serological diagnosis of EBV infection was performed
in the Amiens University Hospital virology laboratory (France). The median age of patients
was 34 years (mean: 38 years, range: 3-82 year) with a sex ratio of 50%. Sixteen of the 91
samples concerned children (<15 years).
This study compared the performance of three automated immunoassays, Architect (Abbott),
Immulite (Siemens) and Liaison (Diasorin), for Epstein-Barr virus (EBV) serology. Ninety-one
serum samples collected in Amiens University Hospital were analyzed for the presence of Viral
Capsid Antigen (VCA) IgG and IgM and Epstein-Barr Nuclear Antigen (EBNA) IgG. The agreement
between the three assays was calculated for each marker individually and for determination of
the EBV profile, based on interpretation of the combination of these three EBV markers.
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