Eating Disorders Clinical Trial
Official title:
Exploration by UHF MRI of Hypothalamic Networks Associated to Feeding in Obesity and Anorexia
Food intake is a motivated behaviour that consists of seeking, selecting and ingesting
nutritional resources from the environment. Its main function is therefore, depending on
these conditions, to ensure the supply, in adequate quantities, of the energy and biochemical
substrates necessary for the proper functioning and need of the body. Thus, in addition to
maintaining the body's fat mass level stable, dietary behaviour is part of the energy
homeostasis system and is thus regulated and maintained by the central nervous system.
Although diet regulation involves several brain regions, the way in which these different
regions communicate with each other and influence each other to orchestrate appropriate
eating behaviour is not yet fully characterized. Among the structures of this network, the
hypothalamus, a small structure (less than 1 cm3 in humans) composed of several nuclei such
as the lateral hypothalamus, the arched nucleus or the lateral tuberal nucleus plays a
crucial role.
The investigators propose to use ultra high field (7T) magnetic resonance imaging equiping
the CEMEREM (CHU Timone, APHM, Marseille) to better characterize the role of this crucial
small structure in food intake networks in order to better understand the impact of these
structural and functional disorders observed in patients with anorexia nervosa and obesity
compared to a control population without eating behaviour disorders.
n/a
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