The Role of Estrogen in the Neurobiology of Eating Disorders

Status Recruiting

Clinical Trial Summary

This is a randomized, double blind, placebo-controlled study of the effects of transdermal estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder pathology in hypoestrogenemic female adolescents and young adults (ages 14-35 years) with an eating disorder characterized by extreme dietary restriction and/or excessive exercise. Subjects will be randomized 1:1 to 12 weeks of transdermal estradiol with cyclic progesterone or placebo patches and cyclic placebo pills. Study visits include a screening visit to determine eligibility and visits at baseline, 8 weeks, and 12 weeks. Study procedures comprise behavioral, neuroimaging, and endocrine assessments.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03740204
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Madhusmita Misra, M.D., M.P.H.
Phone	617-726-5790
Email	mmisra@mgh.harvard.edu
Status	Recruiting
Phase	Phase 2
Start date	June 13, 2019
Completion date	December 31, 2025

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