Impact of Neuropsychological Alteration of Patients With Eating Disorders

Eating Disorder Clinical Trial

— NeuropsyTCA  

Official title:

Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04091477
• Other study ID #: RECHMPL19_0436
• Status: Completed
• Start date: October 1, 2019
• Est. completion date: December 30, 2019

Study information

• Verified date: September 2019
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Description:

The investigators will recruit a total of 200 patients with an eating disorder in the university hospital of Montpellier.

Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 200
• Est. completion date: December 30, 2019
• Est. primary completion date: December 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 15 Years to 65 Years

Eligibility

Inclusion criteria :

• Patient with an eating disorder according to DSM-V criteria

• Patient aged from 15 to 65 years

• Patient who performs the day-hospital evaluation

• Patient affiliated to a French social security system

• Patient able to understand the nature, the aim and the methodology of the study For minor one of the legal guardians gave his consent

Exclusion criteria:

• Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)

• Patient's refusal to participate

• Patient protected by law (guardianship or curatorship)

• Pregnant or nursing women. A dosage of ßHCG will be performed to ensure the absence of pregnancy.

Related Conditions & MeSH terms

• Disease
• Eating Disorder
• Feeding and Eating Disorders

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Montpellier	INSERM 1061-Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Level of functional impairment assessed by the clinician with the FAST scale	We aim to investigate the link between global functioning and decision making abnormalities of patients with eating disorder.; The Functioning Assessment Short Test (FAST) is composed of 24 items assessing various dimensions of daily functionning. Each item is ranged from 0 (no difficulty) to 3 (major difficulty) like a likert scale. The FAST is subdivided in 6 subscales : Autonomy (from 0 to 12), Professional activity (from 0 to 15), Cognitive functioning (from 0 to 15), Finances (from 0 to 6), interpersonal relationships (from 0 to 18) and Hobbies (from 0 to 6). The total score is the sum of the 6 subscales from 0 to 72. A hight score reveal hight difficulties in daily functionning	1 day
Secondary	Decision making assessed by the Iowa Gambling Task	We aim to investigate the link between decision making abnormalities and eating disorder caracteristicus	1 day
Secondary	Level of cognitive flexibility assessed by the Brixton test	We aim to investigate the link between cognitive flexibility abnormalities and eating disorder caracteristicus	1 day
Secondary	Level of central coherence assessed by the Rey Figure Test	We aim to investigate the link between central coherence abnormalities and eating disorder caracteristicus	1 day