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Clinical Trial Summary

This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation.


Clinical Trial Description

Eating disorders are a public health issue. It has been recently reported the importance of immune system modifications in eating disorders physiopathology, involving autoantibodies directed against neuropeptides regulating food intake. A recent study of laboratory INSERM 1073 showed the existence of an intestinal bacterial protein exhibiting structural similarities with α-MSH: ClpB. The autoAc directed against the latter also react with α-MSH because of these similarity of structures, thus leading to a potential digestive origin of these autoAc. To consolidate this new etiopathogenic assumption, a large clinical study is necessary with analysis of patients autoAc profiles. a monocentric study with inclusion of 240 patients over 2 years and 80 healthy volunteers is proposed.

This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation. Nutritional modulations (probiotic, amino-acid…) could constitute an interesting therapeutic perspective in the future. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03510533
Study type Interventional
Source University Hospital, Rouen
Contact Najate EL MACHKOURI ACHAMRAH, MD, PhD
Phone 2 32 88 57 05
Email Najate.Achamrah@chu-rouen.fr
Status Not yet recruiting
Phase N/A
Start date May 2018
Completion date January 2021

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