Effects of Exercise on Energy Intake-Prescription of Resistance Exercise

Eating Behavior Clinical Trial

Official title:

Effects of Acute Resistance Exercise With Varying Training Volume and Rest Intervals Under Equal Load on Appetite Control, Food Reward, and Energy Intake: a Five-arm Crossover Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06223282
• Other study ID #: 202112HM039
• Status: Completed
• Phase: N/A
• Start date: October 28, 2022
• Est. completion date: March 31, 2023

Study information

• Verified date: January 2024
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that different inter-set rest and training volume would affect subjective appetite and energy intake.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: March 31, 2023
• Est. primary completion date: March 31, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• Age: 20-30

• Healthy male

Exclusion Criteria:

• No acute or chronic musculoskeletal symptoms

• Smoking

• Alcohol or drug abuse

• Failure to conduct resistance exercise

Related Conditions & MeSH terms

• Eating Behavior
• Food Reward

Intervention

Other:
• short inter-set rest resistance exercise
Subjects in short inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 60 sec of rest between sets.
• medium inter-set rest
Subjects in medium inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 120 sec of rest between sets.
• long inter-set rest
Subjects in long inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 180 sec of rest between sets.
• medium inter-set rest with failure
Subjects in long inter-set rest trial performed 3 sets per exercise, repeated to failure with load of 70%-1RM with 120 sec of rest between sets.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Subjective appetite	The appetite perceptions were obtained through a 0-100 mm visual analog scale. The variables assessed included perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".	4-hour during each study intervention
Primary	Change in acyl-Ghrelin	acyl-Ghrelin in pg/mL	4-hour during each study intervention
Primary	Change in total-Ghrelin	total-Ghrelin in pg/mL	4-hour during each study intervention
Primary	Change in PYY	PYY in pg/mL	4-hour during each study intervention
Primary	Change in active-GLP-1	active-GLP-1 in pg/mL	4-hour during each study intervention
Primary	Change in total-GLP-1	total-GLP-1 in pg/mL	4-hour during each study intervention
Primary	Change in lactate	insulin in mmol/L	4-hour during each study intervention
Secondary	Explicit liking	A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How pleasant would it be to taste some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."	4 hours during each study intervention
Secondary	Explicit wanting	A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How much do you want some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."	4 hours during each study intervention
Secondary	Implicit wanting	Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The implicit wanting calculation involved further consideration of response time data based on preference choices using a standardized equation.	4 hours during each study intervention
Secondary	Relative preference	Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The relative preference was the sum of the times each type of food was chosen, with a maximum value of 48 and a minimum value of 0.	4 hours during each study intervention
Secondary	Fat appeal bias	Fat preference (high or low) was calculated by subtracting the mean low-fat scores from the mean high-fat scores. Positive values suggest a preference for high-fat foods, while negative scores indicate a preference for low-fat or savory foods, and a score of 0 signifies an equal preference between fat content.	4 hours during each study intervention
Secondary	Taste appeal bias	Taste preference (savoury or sweet) was calculated by subtracting the mean savory scores from the mean sweet scores. Positive values suggest a preference for sweet foods, while negative scores indicate a preference for savory foods, and a score of 0 signifies an equal preference between taste categories.	4 hours during each study intervention
Secondary	Change in glucose	glucose in mg/dL	4 hours during each study intervention
Secondary	Change in TG	TG in mg/dL	4 hours during each study intervention
Secondary	Change in insulin	insulin in mU/L	4 hours during each study intervention
Secondary	Energy intake	Participants are required to record their diet for the day before, the current day, and the day following the experiment.	3 days during each study intervention