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Early Rheumatoid Arthritis clinical trials

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NCT ID: NCT04752748 Completed - Clinical trials for Early Rheumatoid Arthritis

Power Doppler in Hand Joints of Early RA Patients

Start date: August 2014
Phase:
Study type: Observational

It is a prospective case-control study with women diagnosed early rheumatoid arthritis. Three therapeutic failures were considered: failure 1 - to the first Disease-modifying antirheumatic drugs (DMARDs) (methotrexate); failure 2 - to the second DMARDs (leflunomide) and failure 3 - to the first immunobiological drugs (adalimumab). Ultrasound was performed bilaterally on the 2nd and 3rd metacarpophalangeal joints (MCFs), proximal interphalangeal joints (IFPs), and wrists (US10). Ultrasound measurements (qualitative and semi-quantitative) evaluated: 1 - inflammatory: synovial and tenosynovial proliferation in gray scale and power Doppler (0-3); 2 - joint damage: bone erosion (qualitative and semi-quantitative) and cartilage damage (qualitative and semi-quantitative). Clinical and laboratory variables were also assessed blindly at baseline and after 12, 24 e 48 weeks.

NCT ID: NCT01768923 Completed - Clinical trials for Early Rheumatoid Arthritis

Early RA Vascular Randomised Controlled Study

Start date: October 2012
Phase: N/A
Study type: Interventional

To investigate the effect of two tight-control treatment strategies, aiming at 1) 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) definition of remission compare with 2) minimal disease activity (Disease Activity Index in 28 joints [DAS28] <2.6), on arterial stiffness in early rheumatoid arthritis (RA) patients. To compare the effect of two treatments on arterial stiffness in Early Rheumatoid Arthritis

NCT ID: NCT01762176 Completed - Clinical trials for Early Rheumatoid Arthritis

Early RA MRI Early Intensive Treatment Study

Start date: October 2012
Phase: N/A
Study type: Interventional

To compare the effectiveness of two treatment strategies in early rheumatoid arthritis (ERA), namely the delayed usual care and early intensive care, in Hong Kong. - The delayed usual care reflects the usual treatment practice in Hong Kong - The early intensive care includes tight monitoring and immediate adjustment of therapy

NCT ID: NCT01185301 Completed - Clinical trials for Early Rheumatoid Arthritis

Study to Determine the Effects of Different Doses of Methotrexate (MTX) When Taken With Adalimumab in Subjects With Early Rheumatoid Arthritis (RA)

CONCERTO
Start date: October 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the effects of different doses of methotrexate (MTX) when taken with adalimumab in subjects with early rheumatoid arthritis (RA).

NCT ID: NCT00195663 Completed - Clinical trials for Early Rheumatoid Arthritis

Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid Arthritis

PREMIER
Start date: December 2000
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the safety and efficacy of adalimumab in combination with methotrexate in patients with recent onset rheumatoid arthritis (RA), and to assess the long-term safety and maintenance of efficacy after treatment with adalimumab for up to 10 years.