Clinical and Molecular Aspects of Early Osteoarthritis

Early Osteoarthritis Clinical Trial

Official title:

Clinical and Molecular Aspects of Early Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04267510
• Other study ID #: RECHMPL20_0085
• Status: Completed
• Start date: January 1, 2013
• Est. completion date: January 1, 2020

Study information

• Verified date: February 2020
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis. To our knowledge, there are no large-scale genetic studies on people with early osteoarthritis. The investigators therefore sought to study the causes of monogenic osteoarthritis in people suffering from early non-syndromic osteoarthritis.

Material and method From 2013 to 2019, experts in constitutional bone disease sent patients with non-syndromic early osteoarthritis for genetic analysis to our center of competence for constitutional bone diseases. The sequencing of a panel of genes was carried out by NGS.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: January 1, 2020
• Est. primary completion date: December 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 7 Years and older

Eligibility

Inclusion Criteria:

• Patients with early osteoarthritis who have undergone genetic sequencing

Exclusion Criteria:

• Patients refusing to participate in research

Related Conditions & MeSH terms

• Early Osteoarthritis
• Osteoarthritis

Locations

Country	Name	City	State
France	UH Montpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	identification of genetic mutation	sequencing out by NGS	1 day
Primary	number of genetic mutation	sequencing out by NGS	1 day