Enhancing Sensorimotor Processing in Children With Dystonia

Dystonia Clinical Trial

Official title:

Enhancing Cortical Sensorimotor Processing in Children/Young People With Dystonia and Dystonic Cerebral Palsy - An Observational Study to Evaluate Whether Neurofeedback Can Enhance Modulation of the mu Brain Rhythm in Children and Young People With Dystonia/Dystonic Cerebral Palsy

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05612464
• Other study ID #: 317454
• Status: Not yet recruiting
• Start date: February 1, 2023
• Est. completion date: February 1, 2028

Study information

• Verified date: October 2022
• Source: King's College London
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury. The most common cause in childhood is dystonic cerebral palsy (CP) which often affects the whole body.

The underlying mechanisms are unknown, but there is growing evidence to implicate abnormal brain processing by the brain of incoming "sensory" information (e.g., signals to the brain from our senses of touch and body position): the distorted perception of these signals disrupts the way the brain produces instructions for planning and performing movements.

The investigator's previous studies have shown that the way the brain processes sensory information related to movement is abnormal in children with dystonia and dystonic CP, by using methods that record the EEG (electroencephalogram - brain wave signals) and/or EMG (electromyogram - electrical signal from muscles). A specific brain rhythm (called mu) typically shows well-defined changes in response to movement, and reflects processing of sensory information. The investigator's work shows these rhythm changes are abnormal in children with dystonia/dystonic CP.

This study will explore if these findings can improve treatment. In particular the study team will investigate whether children and young people with dystonia/dystonic CP can enhance these mu rhythm responses during a movement task by using feedback of their brain rhythms displayed as a cartoon/game on a computer. The investigators will also assess whether enhanced mu activity is associated with improved movement control. This would open future possibilities to use such devices for therapy/rehabilitation.

Children and young people with dystonia/dystonic CP aged 5-25 years will be recruited, along with age-matched controls. Studies will last 2-3 hours with time for breaks and will be conducted at Evelina London Children's Hospital and Barts Health Trust, with the option for home visits if preferable for families.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 90
• Est. completion date: February 1, 2028
• Est. primary completion date: February 1, 2028
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years to 25 Years

Eligibility

Key inclusion criteria

Control Group:

• Age 5 -25 years

• No known disorder of movement

• Able to understand and participate in study.

Primary dystonia group (isolated genetic or idiopathic):

• Age 5-25 years

• Clinical dystonia - as confirmed on clinical assessment by consultant paediatric neurologist.

• Genetic or idiopathic aetiology.

• No other neurological abnormality.

• Normal cranial magnetic resonance imaging (MRI).

• Able to understand and participate in study.

Dystonic Cerebral Palsy Group:

• Age 5-25 years

• Clinical dystonia/dyskinesia - as confirmed on clinical assessment by consultant paediatric neurologist.

• Documented history of perinatal hypoxic-ischaemic encephalopathy (HIE), prematurity <35 weeks or kernicterus.

• Predominant dystonia/dyskinesia / Minimal spasticity

• MRI findings in keeping with acute perinatal HIE, prematurity or kernicterus (including classical pattern of damage to thalami, basal ganglia and peri-rolandic cortex, periventricular leukomalacia or ischaemic parenchymal injury).

• Able to understand and participate in study.

Key exclusion criteria

Control Group:

• Age <5 or >25 years

• Any known disorder of movement.

Primary dystonia group (isolated genetic or idiopathic):

• Age < 5 or >25 years

• Presence of other neurological abnormality in addition to dystonia.

• Abnormal cranial MRI.

Dystonic Cerebral Palsy Group:

• Age < 5 or >25 years

• No clear history of perinatal HIE, prematurity or kernicterus.

• Predominant spasticity.

• MRI scan not compatible with perinatal HIE, prematurity or kernicterus

Related Conditions & MeSH terms

• Cerebral Palsy
• Dystonia
• Dystonia, Primary
• Dystonia, Secondary
• Dystonia; Idiopathic
• Dystonic Cerebral Palsy
• Dystonic Disorders

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
n/a

Sponsors (6)

Lead Sponsor	Collaborator
King's College London	Barts & The London NHS Trust, Guy's and St Thomas' NHS Foundation Trust, Imperial College London, University of Bristol, University of Calgary

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in mu modulation between trials with and without biofeedback		During the procedure