Agency in Dystonia — AGENT10  

Dystonia, Primary Clinical Trial

Official title: Neuronal Correlates of Agency in Dystonia

Status Active, not recruiting

Clinical Trial Summary

In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia:

(i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.

Clinical Trial Description

This is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims.

The battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. The magnetic resonance acquisition protocol will include MP2RAGE structural (10 min duration), multi echo (3 echo times) multiband (MB factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration) ;

Related Conditions & MeSH terms

• Dystonia
• Dystonia, Primary
• Dystonic Disorders

• NCT number: NCT03351218
• Study type: Interventional
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Status: Active, not recruiting
• Phase: N/A
• Start date: October 23, 2017
• Completion date: October 15, 2022