Dyspnea Clinical Trial
Official title:
The Safety and Efficacy of Current FFR Measurement in NTUH Health Care System
FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature. In this study, the investigator would like to evaluate the effectiveness and safety of NTUH experience in FFR prospectively. First, the investigator will record any intracoronary (IC) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. Second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. Finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-BNP), and high sensitivity C- reactive protein (hsCRP) will be checked and determined their relationships with the maximum dosage of IC adenosine.
Status | Recruiting |
Enrollment | 250 |
Est. completion date | December 31, 2022 |
Est. primary completion date | December 31, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - Eligible for FFR examination Exclusion Criteria: - Hypersensitivity to adenosine - Severe valvular aortic stenosis - Resting heart rate less than 50 beats per minute |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital Hsin-Chu branch | Hsinchu |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital Hsin-Chu Branch |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | The relationship between pro-BNP,hs-CRP and maximum dosage of IC adenosine | Determine the correlation of pro-BNP,,hs-CRP and peak dosage of IC adenosine with FFR protocol in NTUH system | 1 day | |
Primary | Adenosine related adverse event | Including
Bradyarrhythmia including sinus pause and transient AV block Acute respiratory failure define by respiratory distress which need mechanical ventilator support |
24 hours | |
Primary | Major adverse cardiac event (MACE) | MACE including target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death | 2 year | |
Secondary | The relationship between left ventricular diastolic pressure and maximum dosage of IC adenosine | Determine the correlation of left ventricular diastolic pressure and peak dosage of IC adenosine with FFR protocol in NTUH system | 1 hour |
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